Julen Lopetegui's side were seen off 2-0 by Liverpool on Wednesday evening - the same night that Spurs were dumped out of the FA Cup 1-0 by Sheffield United in the fifth round - and here Sports Mole rounds up the team news for both clubs.
WOLVERHAMPTON WANDERERS vs. TOTTENHAM HOTSPUR
WOLVERHAMPTON WANDERERS
Out: Sasa Kalajdzic (ACL), Chiquinho (knee), Hwang Hee-chan (thigh), Boubacar Traore (groin), Hugo Bueno (hamstring)
Doubtful: Matheus Cunha (ankle)
Sports Mole's predicted XI: Sa; Semedo, Dawson, Kilman, Ait-Nouri; Lemina, Neves; Traore, Moutinho, Podence; Jimenez
TOTTENHAM HOTSPUR
Out: Yves Bissouma (ankle), Hugo Lloris (knee), Rodrigo Bentancur (ACL), Ryan Sessegnon (hamstring)
Doubtful: Emerson Royal (knee)
Sports Mole's predicted XI: Forster; Romero, Dier, Lenglet; Emerson, Skipp, Hojbjerg, Davies; Kulusevski, Kane, Son
For data analysis of the most likely results, scorelines and more for this match please click here.