On the back of losing 5-0 to Brighton & Hove Albion last weekend, Chris Wilder was always going to tinker with his Blades starting lineup.
Mason Holgate is an enforced absentee courtesy of his sending off against the Seagulls, and he is joined by Wes Foderingham Ben Osborn and William Osula dropping out of the side.
Goalkeeper Ivo Grbic returns between the sticks for the first time since suffering concussion against Crystal Palace soon after his arrival from Atletico Madrid.
Auston Trusty is restored to the back three, Oliver Norwood comes back into the midfield and Rhian Brewster gets the nod in attack.
Meanwhile, Gary O'Neil has opted against making any alterations to the Wolves XI that started the 2-1 triumph over Tottenham Hotspur.
Although Matheus Cunha is the only senior absentee right now, the only players who may have been considered for a recall are Tommy Doyle and Jean-Ricner Bellegarde.
Instead, O'Neil has stuck with Pablo Sarabia as the player to link midfield and attack, with Hwang Hee-chan or Pedro Neto to be deployed down the middle.
Despite coming through 45 minutes for the Under-21s earlier this week, young attacker Noha Lemina is again not selected among the replacements.
Wolverhampton Wanderers: Sa; Kilman, Dawson, Toti; Semedo, Lemina, Gomes, Ait-Nouri; Neto, Hwang, Sarabia
Subs: Bentley, Doherty, S.Bueno, Traore, H.Bueno, Doyle, Bellegarde, Chirewa, Fraser
Sheffield United: Grbic; Trusty; Ahmedhodzic, Robinson; Bogle, Souza, Norwood, Hamer; Larouci; McAtee; Brewster
Subs: Foderingham, McBurnie, Davies, Osborn, Arblaster, Curtis, Osula, Brooks, Sasnaukas