Head coach Gary O'Neil has had to work with a depleted squad of late, owing to players moving elsewhere and being on international duty at the Africa Cup of Nations and Asian Cup.
Although O'Neil is able to welcome back Algeria international Rayan Ait-Nouri, who is selected on the substitutes' bench, he is missing Pablo Sarabia due to a minor injury.
That has led to Jean-Ricner Bellegarde being drafted into the starting lineup, likely playing down the right of a front three alongside Matheus Cunha and Pedro Neto.
Teenager Nathan Fraser, who scored in the third-round replay against Brentford, is selected on a young substitutes' bench with Harvey Griffiths and Tawanda Chirewa.
Meanwhile, Carlos Corberan has made two changes to the West Brom XI that started the 2-0 defeat to Norwich City last weekend.
Goalkeeper Josh Griffiths has been recalled between the sticks for just his third start of the season, taking the spot of Alex Palmer.
With Alex Reach being ruled out through injury, Nathaniel Chalobah is selected in a midfield three alongside Okay Yokuslu and Alex Mowatt.
West Bromwich Albion: Griffiths; Furlong, Bartley, Kipre, Townsend; Yokuslu, Mowatt, Chalobah; Wallace, Thomas-Asante, Swift
Subs: Palmer, Pieters, Pipa, Fellows, Malcolm, Taylor, Whitwell, Hall, Heard
Wolverhampton Wanderers: Sa; Kilman, Dawson, Toti; Semedo, Doyle, Lemina, Doherty; Bellegarde, Cunha, Neto
Subs: Bentley, King, Ait-Nouri, S.Bueno, H.Bueno, Hodge, Griffiths, Chirewa, Fraser