The striker is suspended following his red card at Southampton last weekend so Jarrod Bowen could move into a central attacking role.
Vladimir Coufal, Angelo Ogbonna and Said Benrahma should return after being rested for Thursday's Europa League win against Dinamo Zagreb.
Edinson Cavani will miss out again for Manchester United as he continues to battle a muscle strain.
The Uruguay striker could return to main first-team training next week, but will definitely miss the West Ham trip.
Aaron Wan-Bissaka is free to feature as his Champions League suspension does not extend to the Premier League.
West Ham provisional squad: Fabianski, Coufal, Zouma, Ogbonna, Cresswell, Rice, Soucek, Lanzini, Fornals, Benrahma, Bowen, Areola, Fredericks, Dawson, Diop, Johnson, Masuaku, Noble, Kral, Yarmolenko, Randolph.
Manchester United provisional squad: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, Van De Beek, Pogba, Fernandes, Sancho, Ronaldo, Heaton, Bailly, Varane, Dalot, Matic, Mata, Lingard, Greenwood, Martial.
CSKA Moscow 
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Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
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Manchester City 
Feyenoord 
Sporting CP 
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FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
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Club Brugge 
Dinamo Zagreb 
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Benfica 
PSV 
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