Ange Postecoglou's men eked out a 1-0 win over Burnley in the third round, while the Citizens swept aside Huddersfield Town 5-0, and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. MANCHESTER CITY
TOTTENHAM HOTSPUR
Out: Ryan Sessegnon (thigh), Pape Sarr (international), Yves Bissouma (international), Son Heung-min (international), Alejo Veliz (knee), Giovani Lo Celso (thigh), Manor Solomon (knee)
Doubtful: Dane Scarlett (unspecified), James Maddison (ankle), Ben Davies (thigh)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Hojbjerg, Bentancur; Johnson, Kulusevski, Werner; Richarlison
MANCHESTER CITY
Out: Erling Haaland (foot), Manuel Akanji (knock)
Doubtful: Ederson (knee), John Stones (ankle)
Sports Mole's predicted XI: Ortega; Walker, Dias, Ake, Gvardiol; Rodri, Kovacic; Silva, De Bruyne, Foden; Alvarez
For data analysis of the most likely results, scorelines and more for this match please click here.