Ange Postecoglou's men were forced to accept a point in a 2-2 draw with Everton last weekend, while their visitors blew Crystal Palace away in a 4-1 derby triumph, and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. BRIGHTON & HOVE ALBION
TOTTENHAM HOTSPUR
Out: Manor Solomon (knee), Ryan Sessegnon (thigh)
Doubtful: Yves Bissouma (international/illness), Son Heung-min (international), Giovani Lo Celso (thigh)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Hojbjerg; Kulusevski, Maddison, Son; Richarlison
BRIGHTON & HOVE ALBION
Out: Simon Adingra (international), James Milner (thigh), Julio Enciso (knee), Solly March (knee), Joel Veltman (knee)
Doubtful: Kaoru Mitoma (international)
Sports Mole's predicted XI: Verbruggen; Van Hecke, Igor, Dunk; Hinshelwood, Gross, Gilmour, Lamptey; Buonanotte, Pedro; Ferguson
For data analysis of the most likely results, scorelines and more for this match please click here.