Ange Postecoglou's men were beaten by Manchester City in the fourth round of the FA Cup on Friday evening, after being held to a 2-2 draw in their most recent Premier League match against Manchester United; the Bees beat Nottingham Forest last time out.
Like their visitors, Spurs' squad is still short of some key players, so Sports Mole rounds up the latest team news ahead of the clubs' midweek clash.
TOTTENHAM HOTSPUR vs. BRENTFORD
TOTTENHAM HOTSPUR
Out: Alejo Veliz (knee), Manor Solomon (knee), Giovani Lo Celso (thigh), Son Heung-min, Pape Sarr, Yves Bissouma (all international duty)
Doubtful: Ryan Sessegnon (hamstring)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Hojbjerg, Bentancur; Johnson, Kulusevski, Werner; Richarlison
BRENTFORD
Out: Sergio Reguilon (ineligible), Rico Henry (knee), Aaron Hickey (thigh), Bryan Mbeumo (ankle), Kevin Schade (groin), Yoane Wissa, Saman Ghoddos and Frank Onyeka (all international duty)
Doubtful: Christian Norgaard (ankle)
Sports Mole's predicted XI: Flekken; Collins, Pinnock, Mee; Roerslev, Janelt, Jensen, Damsgaard, Lewis-Potter; Toney, Maupay
For data analysis of the most likely results, scorelines and more for this match please click here.
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen