Ralph Hasenhuttl's side ended their winless run with a 1-0 triumph over Bournemouth in midweek, while the Gunners overcame PSV Eindhoven in the Europa League by the same scoreline, and here Sports Mole rounds up the team news for both clubs.
SOUTHAMPTON vs. ARSENAL
SOUTHAMPTON
Out: Ainsley Maitland-Niles (ineligible), Romeo Lavia (thigh), Armel Bella-Kotchap (shoulder), Valentino Livramento (knee), Kyle Walker-Peters (hamstring)
Doubtful: None
Sports Mole's predicted XI: Bazunu; Lyanco, Salisu, Caleta-Car; Elyounoussi, Ward-Prowse, S. Armstrong, Diallo, Perraud; Aribo, Adams
ARSENAL
Out: Mohamed Elneny (hamstring), Emile Smith Rowe (groin)
Doubtful: Oleksandr Zinchenko (calf), Bukayo Saka (calf)
Sports Mole's predicted XI: Ramsdale; White, Saliba, Gabriel, Tomiyasu; Xhaka, Partey; Saka, Odegaard, Martinelli; Jesus
For data analysis of the most likely results, scorelines and more for this match please click here.