While the hosts have several selection concerns, United come into the game following a rare week's rest - as Sunday's hotly-anticipated Premier League encounter with Liverpool was postponed after supporters protested on the Old Trafford pitch.
Sports Mole now rounds up the latest team news for the two clubs.
ROMA vs. MANCHESTER UNITED
ROMA
Out: Pau Lopez (shoulder), Nicolo Zaniolo (ACL)
Doubtful: Jordan Veretout (muscular), Leonardo Spinazzola (muscular), Amadou Diawara (groin), Pedro (thigh), Stephan El Shaarawy (thigh), Riccardo Calafiori (thigh), Carles Perez (thigh)
Sports Mole's predicted XI: Mirante; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Villar, Peres; Pellegrini, Mkhitaryan; Dzeko
MANCHESTER UNITED
Out: Phil Jones (knee), Anthony Martial (knee)
Doubtful: None
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Rashford, Fernandes, Pogba; Greenwood
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen