The home side will enter the contest off the back of a 2-1 win over Real Sociedad in La Liga, while Union Berlin suffered a 2-1 loss to Wolfsburg in the Bundesliga last time out, and here Sports Mole rounds up the team news for the two sides ahead of what will be a historic night for the visitors.
REAL MADRID vs. UNION BERLIN
REAL MADRID
Out: Vinicius Junior (hamstring), Thibaut Courtois (knee), Eder Militao (knee), Arda Guler (knee), Dani Carvajal (muscle)
Doubtful: Ferland Mendy (muscle)
Sports Mole's predicted XI: Kepa; Vazquez, Rudiger, Alaba, F Garcia; Modric, Tchouameni, Camavinga; Bellingham; Joselu, Rodrygo
UNION BERLIN
Out: Laurenz Dehl (Achilles), Andras Schafer (foot), Rani Khedira (calf)
Doubtful: None
Sports Mole's predicted XI: Ronnow; Doekhi, Knoche, Leite; Juranovic, Laidouni, Kral, Aaronson, Gosens; Fofana, Behrens
For data analysis of the most likely results, scorelines and more for this match please click here.