The visitors are currently fourth in the table, eight points behind leaders Girona, while Real Betis sit seventh, one point behind sixth-placed Real Sociedad, and here Sports Mole rounds up the team news.
REAL BETIS vs. BARCELONA
REAL BETIS
Out: Chadi Riad (AFCON), Youssouf Sabaly (AFCON), Abde Ezzalzouli (AFCON), Aitor Ruibal (knee), Ayoze Perez (ankle), Hector Bellerin (ankle)
Doubtful: Juan Miranda (thigh), Guido Rodriguez (ankle), Claudio Bravo (hamstring), Marc Bartra (Achilles)
Sports Mole's predicted XI: Silva; Busto, Pezzella, Papastathopoulos, Abner; Roca, Guardado; Henrique, Isco, Diao; Willian Jose
BARCELONA
Out: Raphinha (thigh), Joao Cancelo (knee), Inigo Martinez (muscle), Marcos Alonso (back), Gavi (knee), Marc-Andre ter Stegen (back)
Doubtful: Andreas Christensen (knock)
Sports Mole's predicted XI: Pena; Roberto, Araujo, Kounde, Balde; F de Jong, Gundogan, Pedri; Yamal, Lewandowski, Torres
For data analysis of the most likely results, scorelines and more for this match please click here.