Los Blancos would claim top spot with a draw in Germany, while Leipzig are bidding to join the holders in the next round of the competition, and here Sports Mole rounds up the team news.
RB LEIPZIG vs. REAL MADRID
RB LEIPZIG
Out: Lukas Klostermann (ankle), Konrad Laimer (ankle), Peter Gulacsi (knee), Marcel Halstenberg (muscle)
Doubtful: Timo Werner (muscle)
Sports Mole's predicted XI: Blaswich; Simakan, Orban, Gvardiol, Raum; Haidara, Schlager; Szoboszlai, Nkunku, Werner; A Silva
REAL MADRID
Out: Karim Benzema (muscle), Dani Ceballos (hamstring), Mariano Diaz (knock), Federico Valverde (bruise), Luka Modric (abductor)
Doubtful: None
Sports Mole's predicted XI: Courtois; Carvajal, Militao, Rudiger, Alaba; Camavinga, Tchouameni, Kroos; Asensio, Rodrygo, Vinicius
For data analysis of the most likely results, scorelines and more for this match please click here.