The two hopefuls will renew hostilities at Old Trafford for the second leg on February 1 following this week's contest, and here Sports Mole rounds up the team news for both clubs.
NOTTINGHAM FOREST vs. MANCHESTER UNITED
NOTTINGHAM FOREST
Out: Dean Henderson (thigh), Chris Wood (ineligible), Omar Richards (calf), Taiwo Awoniyi (groin), Giulian Biancone (knee), Cheikhou Kouyate (thigh), Moussa Niakhate (thigh)
Doubtful: Ryan Yates (illness)
Sports Mole's predicted XI: Hennessey; Aurier, Worrall, Boly, Lodi; Mangala, Danilo, Freuler; Scarpa; Johnson, Gibbs-White
MANCHESTER UNITED
Out: Axel Tuanzebe (unspecified), Donny van de Beek (knee), Jadon Sancho (fitness), Anthony Martial (leg), Diogo Dalot (hamstring)
Doubtful: None
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Varane, Martinez, Malacia; Casemiro, Eriksen; Antony, Fernandes, Rashford; Weghorst
For data analysis of the most likely results, scorelines and more for this match please click here.