Luciano Spalletti's side enter the contest on the back of a 2-1 win over Lazio, while Jurgen Klopp's side drew 0-0 with Everton in the Merseyside derby, and here Sports Mole rounds up the team news for both clubs.
NAPOLI vs. LIVERPOOL
NAPOLI
Out: Diego Demme (foot)
Doubtful: Hirving Lozano (head), Victor Osimhen (muscle)
Sports Mole's predicted XI: Meret; Di Lorenzo, Kim, Rrahmani, Rui; Zielinski, Zambo Anguissa, Lobotka; Politano, Raspadori, Kvaratskhelia
LIVERPOOL
Out: Ibrahima Konate (knee), Jordan Henderson (thigh), Alex Oxlade-Chamberlain (thigh), Naby Keita (muscle), Calvin Ramsay (back), Fabio Carvalho (dead leg), Caoimhin Kelleher (groin), Curtis Jones (shin)
Doubtful: None
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Elliott, Fabinho, Milner; Salah, Nunez, Diaz
For data analysis of the most likely results, scorelines and more for this match please click here.