The Serie A leaders start the second leg of their last-16 tie holding a two-goal lead following last month's trip to Germany, leaving the reigning Europa League champions with much to do if they are to gatecrash the last-eight party.
Here, Sports Mole rounds up the latest team news for either side.
NAPOLI vs. EINTRACHT FRANKFURT
NAPOLI
Out: Giacomo Raspadori (thigh)
Doubtful: Alex Meret (wrist), Kim Min-jae (calf), Hirving Lozano (muscular)
Sports Mole's predicted XI: Meret; Di Lorenzo, Kim, Rrahmani, Rui; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
EINTRACHT FRANKFURT
Out: Randal Kolo Muani (suspension), Jesper Lindstrom (ankle), Eric Ebimbe (ankle), Ansgar Knauff (hip)
Doubtful: None
Sports Mole's predicted XI: Trapp; Tuta, Hasebe, Ndicka; Buta, Sow, Rode, Max; Kamada, Gotze; Borre
For data analysis of the most likely results, scorelines and more for this match please click here.