The pair have recovered from a head injury and hamstring issue respectively to feature in an attack-minded Arsenal XI, as Jesus leads the line with support from Gabriel Martinelli and Bukayo Saka.
Odegaard's return means that Kai Havertz has unsurprisingly been demoted to the bench, but Leandro Trossard keeps his place and will seemingly be deployed in a deeper midfield role alongside Declan Rice.
Ben White has also battled back from a knock, but the Englishman has to make do with a spot on the bench, as Takehiro Tomiyasu and Oleksandr Zinchenko both keep their spots in the backline.
As confirmed by Mikel Arteta in his pre-game press conference, Aaron Ramsdale replaces the ineligible David Raya in goal as one of three changes to the Gunners' XI alongside Odegaard and Jesus, as Jorginho also drops down to the bench.
Meanwhile, Brentford boss Thomas Frank has also sprung a couple of surprises, also making a total of three changes to the side from their 3-0 loss to Liverpool a fortnight ago, as Frank Onyeka, Saman Ghoddos and Yehor Yarmoliuk make the first XI.
The latter will be making his first Premier League start in place of Mathias Jensen, who is absent entirely, while the injured Nathan Collins and Mads Roerslev also drop out of the XI.
Brentford: Flekken; Ajer, Mee, Pinnock, Janelt; Norgaard, Onyeka, Yarmoliuk; Ghoddos; Mbeumo, Wissa
Subs: Strakosha, Goode, Maupay, Zanka, Lewis-Potter, Peart-Harris, Baptiste, Brierley, Olakigbe
Arsenal: Ramsdale; Tomiyasu, Saliba, Gabriel, Zinchenko; Odegaard, Rice, Trossard; Saka, Jesus, Martinelli
Subs: Hein, White, Cedric, Kiwior, Jorginho, Havertz, Elneny, Nketiah, Nelson