The Red Devils sit second in the group behind Real Sociedad, while their managerless visitors are six points worse off in third, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER UNITED vs. SHERIFF TIRASPOL
MANCHESTER UNITED
Out: Mason Greenwood (club suspension), Raphael Varane (knee), Axel Tuanzebe (unspecified), Brandon Williams (unspecified), Anthony Martial (back)
Doubtful: Harry Maguire (hamstring), Aaron Wan-Bissaka (unspecified), Donny van de Beek (muscle)
Sports Mole's predicted XI: De Gea; Dalot, Lindelof, Martinez, Shaw; Casemiro, Eriksen; Antony, Fernandes, Sancho; Rashford
SHERIFF TIRASPOL
Out: Armel Zohouri (suspended)
Doubtful: Moussa Kyabou (unspecified)
Sports Mole's predicted XI: Celeadnic; Kiki, Radeljic, Kpozo; Guedes, Badolo, Salifu, Heron; Akanbi, Vizeu, Atiemwen
For data analysis of the most likely results, scorelines and more for this match please click here.