Rob Edwards's men fell to a 3-1 defeat to Sheffield United last weekend, while the Red Devils made it four wins on the trot with a 2-1 beating of Aston Villa, and here Sports Mole rounds up the team news for both clubs.
LUTON TOWN vs. MANCHESTER UNITED
LUTON TOWN
Out: Tom Lockyer (heart), Mads Andersen (calf), Marvelous Nakamba (knee)
Doubtful: Daiki Hashioka (fitness)
Sports Mole's predicted XI: Kaminski; Bell, Osho, Mengi; Ogbene, Barkley, Lokonga, Doughty; Townsend, Morris; Adebayo
MANCHESTER UNITED
Out: Aaron Wan-Bissaka (unspecified), Tyrell Malacia (knee), Anthony Martial (groin), Lisandro Martinez (knee), Mason Mount (calf)
Doubtful: Luke Shaw (unspecified)
Sports Mole's predicted XI: Onana; Dalot, Varane, Maguire, Shaw; Mainoo, Casemiro; Garnacho, Fernandes, Rashford; Hojlund
For data analysis of the most likely results, scorelines and more for this match please click here.