Jurgen Klopp's men beat Chelsea in the final on penalties last year, while the Rams have defeated Mansfield Town and West Bromwich Albion so far this year, and here Sports Mole rounds up the team news for both clubs.
LIVERPOOL vs. DERBY COUNTY
LIVERPOOL
Out: Luis Diaz (knee), Diogo Jota (calf), Joel Matip (calf), Arthur (thigh), Naby Keita (thigh), James Milner (head)
Doubtful: None
Sports Mole's predicted XI: Kelleher; Ramsay, Gomez, Phillips, Tsimikas; Elliott, Bajcetic, Oxlade-Chamberlain, Carvalho; Firmino, Nunez
DERBY COUNTY
Out: Eiran Cashin (suspended), Curtis Davies (knee), James Chester (calf)
Doubtful: David McGoldrick (illness), Tom Barkhuizen (hamstring), Jason Knight (ankle/knee)
Sports Mole's predicted XI: Wildsmith; Smith, Forsyth, Stearman, Roberts; Mendez-Laing, Hourihane, Bird, Dobbin; Osula, Collins
For data analysis of the most likely results, scorelines and more for this match please click here.