The Red Devils will be eliminated from last-16 contention if they lose to the Turkish side, who are third in Group A with five points to their name, and here Sports Mole rounds up the team news for the two clubs.
GALATASARAY vs. MANCHESTER UNITED
GALATASARAY
Out: Davinson Sanchez (hamstring)
Doubtful: Abdulkerim Bardakci (unspecified)
Sports Mole's predicted XI: Muslera; Boey, Bardakci, Ayhan, Angelino; Torreira, Demirbay; Ziyech, Mertens, Zaha; Icardi
MANCHESTER UNITED
Out: Marcus Rashford (suspended), Jadon Sancho (club suspension), Lisandro Martinez (foot), Casemiro (thigh), Amad Diallo (knee), Mason Mount (calf), Jonny Evans (thigh), Christian Eriksen (knee), Tyrell Malacia (knee)
Doubtful: None
Sports Mole's predicted XI: Onana; Wan-Bissaka, Maguire, Lindelof, Shaw; McTominay, Amrabat; Antony, Fernandes, Garnacho; Hojlund
For data analysis of the most likely results, scorelines and more for this match please click here.