The Selecao, who have already qualified for the last 16, need at least a draw to secure top spot in Group G, while Cameroon need to pull off a famous victory to have any hope of reaching the knockout rounds.
Manchester United midfielder Fred and Real Madrid defender Eder Militao are the only two players to keep their place in Brazil's first XI following their 1-0 victory over Switzerland on Monday.
First-choice goalkeeper Alisson Becker has been replaced by Ederson, while 39-year-old right-back Dani Alves will become Brazil's oldest player at the World Cup, joining Militao, Bremer and Alex Telles in the back four.
Indeed, Bremer is one of two players - along with Arsenal's Gabriel Martinelli - who is starting his first game for Brazil, with the latter named in attack along with Rodrygo, Antony and Gabriel Jesus.
Meanwhile, Fred will be joined in centre-midfield alongside Fabinho, with Casemiro, who scored the only goal in the win over Switzerland, dropping to the bench.
As for Cameroon, Rigobert Song has made four changes to his starting lineup, with captain Vincent Aboubakar leading the line after contributing with one goal and one assist in the 3-3 draw with Serbia last time out.
Lyon's Karl Toko Ekambi drops to the bench as a result, while centre-backs Jean-Charles Castelletto and Nicolas Nkoulou have been replaced by Enzo Ebosse and Christopher Wooh.
Moumi Ngamaleu comes in to midfield at the expense of Martin Hongla, while goalkeeper Devis Epassy continues between the sticks after first-choice stopper Andre Onana was sent home earlier this week due to disciplinary reasons.
Cameroon starting lineup: Epassy; Fai, Ebosse, Wooh, Tolo; Anguissa, Kunde; Mbeumo, Choupo-Moting, Ngamaleu; Aboubakar
Subs: Ngapandouetnbu, Mbekeli, Ondoua, Nkoudou, Nsame, Bassogog, Toko Ekambi, Gouet, Mbaizo, Ntcham, Marou
Brazil starting lineup: Ederson; Dani Alves, Militao, Bremer, Telles; Fabinho, Fred; Antony, Rodrygo, Martinelli; Gabriel Jesus
Subs: Weverton, Alisson, Thiago Silva, Marquinhos, Casemiro, Paqueta, Richarlison, Raphinha, Guimaraes, Vinicius Junior, Ribeiro, Pedro