The Magpies ended Manchester United's title defence with a 3-0 hammering in the fourth round, while Mauricio Pochettino's men comfortably got the better of Blackburn Rovers 2-0, and here Sports Mole rounds up the team news for both clubs.
CHELSEA vs. NEWCASTLE UNITED
CHELSEA
Out: Romeo Lavia (ankle), Wesley Fofana (knee), Carney Chukwuemeka (knee), Trevoh Chalobah (thigh), Lesley Ugochukwu (unspecified), Ben Chilwell (hamstring), Reece James (hamstring), Marc Cucurella (ankle), Robert Sanchez (knee)
Doubtful: Noni Madueke (muscle)
Sports Mole's predicted XI: Petrovic; Gusto, Disasi, Badiashile, Maatsen; Caicedo, Fernandez; Sterling, Gallagher, Palmer; Broja
NEWCASTLE UNITED
Out: Lewis Hall (ineligible), Sandro Tonali (suspended), Nick Pope (shoulder), Jacob Murphy (shoulder), Matt Targett (thigh), Javi Manquillo (groin), Elliot Anderson (back), Joe Willock (calf), Harvey Barnes (ankle)
Doubtful: Fabian Schar (glute), Joelinton (hamstring), Kieran Trippier (unspecified), Alexander Isak (groin)
Sports Mole's predicted XI: Dubravka; Krafth, Lascelles, Botman, Burn; Miley, Guimaraes, Longstaff; Ritchie, Wilson, Almiron
For data analysis of the most likely results, scorelines and more for this match please click here.