The Blues have defeated Preston North End and Aston Villa to make it this far, while the in-form Whites dumped Peterborough United and Plymouth Argyle out in the earlier rounds, and here Sports Mole rounds up the team news for both clubs.
CHELSEA vs. LEEDS UNITED
CHELSEA
Out: Wesley Fofana (knee), Reece James (thigh), Lesley Ugochukwu (thigh), Romeo Lavia (thigh), Carney Chukwuemeka (ankle), Benoit Badiashile (groin), Christopher Nkunku (unspecified), Cesare Casadei (cup-tied)
Doubtful: Thiago Silva (groin), Marc Cucurella (ankle)
Sports Mole's predicted XI: Sanchez; Gusto, Gilchrist, Chalobah, Colwill; Gallagher, Fernandez; Madueke, Palmer, Mudryk; Sterling
LEEDS UNITED
Out: Karl Darlow (finger), Pascal Struijk (groin), Stuart Dallas (hip)
Doubtful: Sam Byram (leg), Georginio Rutter (hip), Crysencio Summerville (ankle), Daniel James (bruise), Patrick Bamford (calf/ankle)
Sports Mole's predicted XI: Meslier; Roberts, Ampadu, Cooper, Firpo; Gruev, Kamara; Gnonto, Gray, Anthony; Piroe
For data analysis of the most likely results, scorelines and more for this match please click here.
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
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Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
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Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen