The Dons have already pulled off a shock result in this year's tournament, defeating Coventry City 2-1 in round one, and here Sports Mole rounds up the team news for both clubs.
CHELSEA vs. AFC WIMBLEDON
CHELSEA
Out: Armando Broja (knee), Wesley Fofana (knee), Marcus Bettinelli (unspecified), Christopher Nkunku (knee), Carney Chukwuemeka (knee), Reece James (thigh), Trevoh Chalobah (thigh), Romeo Lavia (fitness)
Doubtful: Benoit Badiashile (thigh), Mykhaylo Mudryk (unspecified)
Sports Mole's predicted XI: Petrovic; Humphreys, Colwill, Cucurella; Gusto, Ugochukwu, Gallagher, Maatsen; Madueke, Burstow, Moreira
AFC WIMBLEDON
Out: Paul Kalambayi (knee), Huseyin Biler (hamstring)
Doubtful: Jake Reeves (hamstring), Armani Little (unspecified)
Sports Mole's predicted XI: Tzanev; Ogundere, Lewis, Johnson, Brown; Tilley, Ball, Pell, McLean; Al-Hamadi, Bugiel
For data analysis of the most likely results, scorelines and more for this match please click here.