On Sunday, the Blues suffered a 1-0 defeat to Liverpool in the EFL Cup final, being taken to extra time before conceding the decisive goal with two minutes remaining.
Viewing the FA Cup as a potential route back into Europe, Pochettino has been unable to completely rotate his squad, opting to make just five alterations.
Goalkeeper Robert Sanchez makes his first appearance since December having overcome a knee injury, Djordje Petrovic dropping down to the substitutes' bench.
Alfie Gilchrist and Trevoh Chalobah have been included in defence, with Levi Colwill and Ben Chilwell being handed rests by Pochettino.
Conor Gallagher and Cole Palmer also feature among the replacements, with Noni Madueke and Mykhaylo Mudryk being provided with chances to impress.
Meanwhile, Daniel Farke has made five changes of his own to his Leeds side, Mateo Joseph getting the nod down the middle of the attack.
Connor Roberts, Liam Cooper, Daniel James and Jaidon Anthony have also been brought into the side.
Ilia Gruev, Glen Kamara, Wilfried Gnonto, Georginio Rutter and Crysencio Summerville are the players to drop out of the team on the back of Friday's 3-1 victory over Championship leaders Leicester City.
Chelsea: Sanchez; Gilchrist, Disasi, Chalobah, Gusto; Madueke, Caicedo, Fernandez, Mudryk; Sterling, Jackson
Subs: Petrovic, Colwill, Murray-Campbell, Chilwell, Samuels-Smith, Harrison, Taurianen, Gallagher, Palmer
Leeds United: Meslier; Roberts, Rodon, Cooper, Firpo; Ampadu, Gray; James, Piroe, Anthony; Joseph
Subs: Klaesson, Van den Heuvel, Byram, Cresswell, Shackleton, Kamara, Summerville, Gnonto, Bamford