The Gunners are currently four points clear of second-placed Manchester City in the table, while Southampton are bottom, four points from safety, and here Sports Mole rounds up the team news.
ARSENAL vs. SOUTHAMPTON
ARSENAL
Out: Mohamed Elneny (knee), Takehiro Tomiyasu (knee)
Doubtful: Oleksandr Zinchenko (muscle), William Saliba (back)
Sports Mole's predicted XI: Ramsdale; White, Holding, Gabriel, Zinchenko; Xhaka, Thomas, Odegaard; Martinelli, Jesus, Saka
SOUTHAMPTON
Out: Ainsley Maitland-Niles (ineligible), Mohammed Salisu (groin), Mislav Orsic (hip), Valentino Livramento (fitness), Juan Larios (thigh)
Doubtful: Che Adams (calf)
Sports Mole's predicted XI: Bazunu; Perraud, Bednarek, Bella-Kotchap, Walker-Peters; Djenepo, Ward-Prowse, Lavia, Sulemana; Alcaraz, Onuachu
For data analysis of the most likely results, scorelines and more for this match please click here.