Neither the Argentine or Spanish playmakers have made starts in the top flight under Ange Postecoglou, yet the pair feature in a new-look first XI at the Tottenham Hotspur Stadium.
Postecoglou has made a total of four alterations to the team from the defeat at Wolverhampton Wanderers, Destiny Udogie and Rodrigo Bentancur also starting versus the West Midlands outfit.
The return of Udogie has led to Emerson Royal being used in the centre of defence alongside Ben Davies, with Eric Dier only being named as a replacement.
Rodrigo Bentancur makes his first start in a Spurs shirt since recovering from a serious knee injury, featuring alongside Lo Celso in a midfield two.
While Pape Matar Sarr misses out through injury, Pierre-Emile Hojbjerg is surprisingly dropped to the substitutes' bench.
Meanwhile, Unai Emery has made just the one change to his Villa starting lineup, introducing Diego Carlos into the team ahead of Youri Tielemans.
That would seem to indicate that Ezri Konsa will play at right-back and Matty Cash playing in a more-advanced right-midfield role, unless there is a formation switch.
Tottenham Hotspur: Vicario; Porro, Royal, Davies, Udogie; Bentancur, Lo Celso; Kulusevski, Bryan, Son; Johnson
Subs: Forster, Austin, Dorrington, Dier, Skipp, Hojbjerg, Donley, Veliz
Aston Villa: Martinez; Konsa, Carlos, Torres, Digne; Cash, Kamara, Luiz, McGinn; Diaby; Watkins
Subs: Olsen, Tielemans, Moreno, Lenglet, Duran, Bailey, Dendoncker, J.Ramsey, Ireogbunam
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