The teams have been drawn in Group G of the competition alongside five-time winners Brazil, who will take on Serbia in their opening fixture.
Having reached the knockout stages in each of their last two outings at this level, Murat Yakin's men know that the importance of a victory in Al Wakrah on matchday one cannot be overemphasized.
Cameroon, meanwhile, go in search of a first World Cup triumph in two decades which would boost their chances of avoiding an early exit for the first time since 1990.
Here, Sports Mole looks at how the squads of Switzerland and Cameroon stack up against each other ahead of the contest.
SWITZERLAND
Most valuable player:
Manuel Akanji (£25.8m)
Overall squad value:
£242.3m
Most capped player:
Xherdan Shaqiri (109)
Leading goalscorer:
Xherdan Shaqiri (26)
Total caps:
1010
Total goals:
119
Oldest player:
Yann Sommer (33)
Youngest player:
Ardon Jashari (20)
Average age:
27
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Goalkeepers: Yann Sommer (Borussia Monchengladbach), Gregor Kobel (Borussia Dortmund), Jonas Omlin (Montpellier), Philipp Kohn (Red Bull Salzburg)
Defenders: Manuel Akanji (Manchester City), Eray Comert (Valencia), Nico Elvedi (Borussia Monchengladbach), Ricardo Rodriguez (Torino), Fabian Schar (Newcastle United), Silvan Widmer (Mainz 05)
Midfielders: Michel Aebischer (Bologna), Edimilson Fernandes (Mainz 05), Fabian Frei (Basel), Remo Freuler (Nottingham Forest), Ardon Jashari (Luzern), Fabian Rieder (Young Boys), Xherdan Shaqiri (Chicago Fire), Djibril Sow (Eintracht Frankfurt), Renato Steffen (Lugano), Granit Xhaka (Arsenal), Denis Zakaria (Chelsea)
Forwards: Breel Embolo (Monaco), Christian Fassnacht (Young Boys), Noah Okafor (Red Bull Salzburg), Haris Seferovic (Galatasaray), Ruben Vargas (FC Augsburg)
CAMEROON
Most valuable player:
Andre-Frank Zambo Anguissa (£32.7m)
Overall squad value:
£133.6m
Most capped player:
Vincent Aboubakar (91)
Leading goalscorer:
Vincent Aboubakar (33)
Total caps:
649
Total goals:
84
Oldest player:
Eric Maxim Choupo-Moting (33)
Youngest player:
Simon Ngapandouetnbu (19)
Average age:
26.3
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Goalkeepers: Andre Onana (Inter Milan), Devis Epassy (Abha), Simon Ngapandouetnbu (Marseille)
Defenders: Nicolas Nkoulou (Aris), Collins Fai (Al-Tai), Nouhou Tolo (Seattle Sounders), Jean-Charles Castelletto (Nantes), Olivier Mbaizo (Philadelphia Union), Enzo Ebosse (Udinese), Christopher Wooh (Rennes)
Midfielders: Andre-Frank Zambo Anguissa (Napoli), Pierre Kunde (Olympiacos), Samuel Gouet (Mechelen), Martin Hongla (Hellas Verona), Gael Ondoua (Hannover 96), Olivier Ntcham (Swansea City), Jerome Ngom (APEJES de Mfou)
Forwards: Vincent Aboubakar (Al-Nassr), Eric Choupo-Moting (Bayern Munich), Karl Toko Ekambi (Lyon), Christian Bassogog (Shanghai Shenhua), Moumi Ngamaleu (Dynamo Moscow), Jean-Pierre Nsame (Young Boys), Bryan Mbeumo (Brentford), Georges-Kevin Nkoudou (Besiktas), Souaibou Marou (Coton Sport)
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