Bologna vs. Sassuolo (Sunday, 11.30am)
Separated by four points and two places in the Serie A standings, Emilian rivals Bologna and Sassuolo convene at Stadio Renato Dall'Ara on Sunday afternoon.
In the pair's penultimate match of the season, the Rossoblu will seek victory to pull within a point of their 11th-placed visitors, after they fell to a 4-3 defeat against the league's bottom side last weekend.
We say: Bologna 1-2 Sassuolo
Sassuolo are still dangerous opponents on their day, despite recent results to the contrary, and the impetus of a local rivalry should help to inspire them to a first win in five matches.
Not only that, but the Neroverdi rank as high as eighth in terms of their Serie A away record this term, while last week's events demonstrate that an improving Bologna can still be caught out defensively.
Napoli vs. Genoa (Sunday, 2.00pm)
Already confirmed in Serie A's top four, Napoli welcome relegation-threatened Genoa to Stadio Maradona on Sunday, with their visitors in desperate need of points to survive.
Though their Scudetto hopes recently came to an end, the home side have won back-to-back games since, while their Ligurian counterparts pulled off an improbable victory over Juventus to keep the dream alive.
We say: Napoli 1-1 Genoa
Napoli are unbeaten in their last 12 home meetings with Genoa in Serie A - winning on eight occasions and keeping a clean sheet in four of the last five - so precedent is certainly on their side.
They have not been impregnable on home soil this term, though, and the combination of Blessin's organisation and belief from the fightback against Juve could spur the Grifone on to take a potentially precious point.
AC Milan vs. Atalanta (Sunday, 5.00pm)
Just two wins away from guaranteeing a first Scudetto since 2011, AC Milan take the penultimate step towards Serie A supremacy when they meet Atalanta BC on Sunday.
The Lombardy rivals convene at San Siro with the hosts two points clear at the top of the table following four successive wins, while their visitors are embroiled in a battle for European football next term.
We say: AC Milan 1-0 Atalanta BC
Though it ultimately finished 3-2 to Milan in October's reverse fixture - after Atalanta pulled two late goals back to give the scoreline a hint of respectability - this time around, the high stakes could make it a much tighter affair.
Indeed, even a single strike could decide the destiny of the points, and the sense of self-belief forged by recent comebacks can help the Rossoneri edge out La Dea and inch closer to the title.
Cagliari vs. Inter Milan (Sunday, 7.45pm)
Crowned Coppa Italia champions after an epic final in midweek, Inter Milan continue the defence of their Scudetto into Serie A's penultimate round, as they visit relegation-threatened Cagliari on Sunday.
Two points adrift of city rivals Milan with just two games to play, the Nerazzurri must target victory in Sardinia to keep title hopes alive, while their hosts are just inside the drop zone and are equally desperate for three points.
We say: Cagliari 0-2 Inter Milan
Following a 4-0 win in December's reverse fixture at San Siro, Inter are set to complete the double over Cagliari, as they carry over momentum from their Coppa Italia triumph.
With a winnable game remaining on the final day, the hosts may still have a shot at redemption next week, but they have lost half of their home fixtures to this point and are particularly vulnerable defensively.