Ange Postecoglou's men dropped more points on the continent in Thursday's 2-2 draw with Roma, who escaped from North London with a share of the spoils thanks to a last-gasp Mats Hummels equaliser.
Thursday's result was a reality check for Spurs after their incredible 4-0 crushing of Manchester City last weekend, a result that lifted them up to sixth in the Premier League table.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their showdown with Fulham, who were slaughtered 4-1 at home by Wolverhampton Wanderers in Premier League gameweek 12.
Guglielmo Vicario
Status: Out
Type of injury: Ankle
Possible return date: Unknown
First-choice goalkeeper Guglielmo Vicario remarkably played for over an hour at the Etihad with a broken ankle, which he has since undergone surgery for, and Postecoglou has confirmed that the Italian faces months out of action.
Cristian Romero
Status: Major doubt
Type of injury: Toe
Possible return date: December 1 (vs. Fulham)
Postecoglou is keeping his fingers crossed that Cristian Romero will be able to train with the team before the visit of Fulham, but there are still no guarantees that the toe victim will be fit to make his comeback in the derby.
Richarlison
Status: Out
Type of injury: Hamstring
Possible return date: January 15 (vs. Arsenal)
Richarlison's hamstring problem is expected to render him unavailable until the early stages of January, potentially meaning that he could make his comeback in the next North London derby.
Micky van de Ven
Status: Out
Type of injury: Hamstring
Possible return date: December 19 (vs. Manchester United)
Unlike Richarlison, Micky van de Ven's hamstring problem may have completely healed before the end of 2024, but the Dutchman will not be back in action for approximately three more weeks.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Just after making a comeback from one hamstring problem, summer signing Wilson Odobert sustained an even more severe injury in the same area and will be out for the long-term after undergoing an operation.
Mikey Moore
Status: Out
Type of injury: Illness
Possible return date: December 12 (vs. Rangers)
Teenage sensation Mikey Moore has been laid low by a troublesome illness this month, and Postecoglou has conceded that it will be another couple of weeks before the 17-year-old is ready to go again.
TOTTENHAM'S SUSPENSION LIST
Rodrigo Bentancur
Return date: December 12 (vs. Rangers)
Rodrigo Bentancur serves the second of his seven-match domestic suspension for an offensive comment he made about Son Heung-min and South Koreans over the summer, but he will return for Spurs' next Europa League game. In brighter news, attacking protege Will Lankshear is back after his own continental ban in midweek.