The Reds went into the international break with a five-point lead over Manchester City at the summit of the table, while the Saints are four points adrift of safety at the time of writing, and here Sports Mole rounds up the team news for both clubs.
SOUTHAMPTON vs. LIVERPOOL
SOUTHAMPTON
Out: Aaron Ramsdale (finger), Jan Bednarek (knee), Gavin Bazunu (Achilles), Ross Stewart (hamstring), William Smallbone (hamstring)
Doubtful: Flynn Downes (knee), Ryan Fraser (illness)
Sports Mole's predicted XI: McCarthy; Walker-Peters, Sugawara, Stephens, Harwood-Bellis, Manning; Armstrong, Downes, Aribo, Fernandes; Archer
LIVERPOOL
Out: Trent Alexander-Arnold (hamstring), Alisson Becker (hamstring), Diogo Jota (abdominal), Federico Chiesa (fitness)
Doubtful: Harvey Elliott (foot)
Sports Mole's predicted XI: Kelleher; Bradley, Konate, Van Dijk, Robertson; Mac Allister, Gravenberch; Salah, Jones, Gakpo; Nunez
For data analysis of the most likely results, scorelines and more for this match please click here.
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen 
Celta Vigo 
Barcelona 
Benfica 
Estrela Da Amadora 
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Club Brugge