The Magpies haven't been in a domestic cup final since the 1998/99 campaign, but playing the Saints over a two-legged Carabao Cup semi-final looks like a brilliant chance to end that run.
The Toon have the best defensive record in the top-flight and Nick Pope hasn't conceded a goal in his last nine games.
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Meanwhile, Southampton appear to have hit a bit of form under Nathan Jones and have won three of their last four as they look to return to Wembley.
The Saints reached the 2016/17 Carabao Cup final but were beaten 3-2 by Manchester United.
Carabao Cup semi-final first leg to kick-off at 8pm.
Southampton XI: Bazunu, Walker-Peters, Lyanco, Caleta-Car, Salisu, Diallo, Alcaraz, Ward-Prowse, Djenepo, Orsic, Mara.
Subs: Caballero, Bednarek, Perraud, Lavia, Maitland-Niles, Edozie, Elyounoussi, Armstrong, Adams.
Newcastle XI: Pope, Trippier, Schar, Botman, Burn, Guimaraes, Longstaff, Willock, Almiron, Joelinton, Wilson.
Subs: Darlow, Lascelles, Saint-Maximin, Ritchie, Lewis, Isak, Manquillo, Murphy, Anderson.
talkSPORT will have live coverage from the south coast.
Commentary will come from Jim Proudfoot and former West Ham forward Dean Ashton.
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