Pep Guardiola's side enjoyed a run of four consecutive EFL Cups before Liverpool ensured a different name was on the trophy last year.
However, City have already eliminated the reigning holders this time around, having similarly ended Chelsea's hopes across both domestic competitions.
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Southampton are the next top-flight rivals standing in their way, but City have cause to be confident having ran out 4-0 winners when the two sides met back in October.
Live commentary: talkSPORT website stream HERE, via the app HERE
Southampton: Bazunu, Djenepo, Lyanco, Caleta-Car, Salisu, Walker-Peters, Diallo, Lavia, Ward-Prowse, Mara, A Armstrong
Subs: Caballero, Perraud, Finnigan, Elyounoussi, Edozie, Aribo, Orsic, Adams, Morgan
Man City: Ortega, Cancelo, Walker, Laporte, Gomez, Phillips, Gundogan, Palmer, Foden, Alvarez, Grealish
Subs: Ederson, Ake, Haaland, Rodri, De Bruyne, Silva, Akanji, Mahrez, Lewis
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