The hosts thrashed their opponents 3-0 and gained a measure of revenge for defeat in their World Cup play-off match.
But Steve Clarke's side were beaten 3-0 by the Boys in Green in the reverse fixture, so this will be a tough test.
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Stephen Kenny's men haven't played any football since June but have managed draws against Ukraine and Belgium this year as well as the win over Scotland.
UEFA Nations League clash at Hamden Park to kick-off at 7:45pm
Scotland thrashed Ukraine 3-0 while Republic of Ireland haven't played since June
Scotland: Gordon, Hickey, McKenna, Hendry, Tierney, McTominay, McGregor, McGinn, Armstrong, Christie, Dykes
Subs: Kelly, McCrorie, Taylor, Gallagher, Porteous, Adams, Gilmour, Ralston, Doig, Fraser, Jack, McLean
Republic of Ireland: Bazunu, Collins, O'Shea, Egan, Doherty, McClean, Molumby, Knight, Cullen, Obafemi, Parrott
Subs: Travers, O'Leary, Coleman, Duffy, Robinson, Hendrick, Hourihane, Browne, Hogan, Ogbene, Brady, O'Dowda
talkSPORT will have regular updates throughout the evening
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