Venezia vs. Parma (Saturday, 2.00pm)
Two teams that struggle to retain leads will clash at Stadio Pier Luigi Penzo on Saturday afternoon, as Venezia host Parma.
Since both were promoted back to Serie A last season, they have dropped the most points from winning positions - no fewer than 23 combined - leaving them stuck near the foot of the standings.
We say: Venezia 2-2 Parma
Though Parma are more potent than their hosts up front, they have consistently paid for some costly slip-ups, losing seven points from leading positions away from home.
For all their flaws, Venezia are yet to drop points from in front at Stadio Penzo, and they should at least secure a home draw.
Cagliari vs. AC Milan (Saturday, 5.00pm)
After mastering the European champions in Madrid, AC Milan must return to Serie A duty on Saturday evening, when they head south to Cagliari.
The Rossoneri swept aside concerns about their domestic form to secure a famous Champions League success in midweek, while their hosts have just lost three games on the spin to slip down the table.
We say: Cagliari 0-2 AC Milan
Milan have scored a league-high 65% of their goals in the first half this season, while only two teams have found the net less than Cagliari before the break.
So, expect the Rossoneri to take a lead that they will not relinquish, as they are improving at the back and their hosts are lightweight up front.
Juventus vs. Torino (Saturday, 7.45pm)
Aiming to continue their long dominance of the Turin derby, Serie A giants Juventus will host city rivals Torino on Saturday evening.
After a midweek draw in Europe, Juve now seek a 19th straight game without defeat to their neighbours, which would extend a record run in the Derby della Mole.
We say: Juventus 2-0 Torino
Juventus have conceded the fewest shots in total (93) and on target (27) in Serie A thus far, while Torino have conceded the most overall (188).
That points to a comfortable home win for derby dominators Juve, who must surely keep another clean sheet against Toro's ailing attack.