Como vs. Parma (Saturday, 2.00pm)
Promoted together last season, struggling Serie A newcomers Como and Parma will convene at Stadio Sinigaglia on Saturday afternoon.
While the hosts have started to recover from a rocky start in the top flight, their Emilian counterparts have spilt a series of points and sit close to the foot of the standings.
We say: Como 2-2 Parma
Neither side has been able to keep the back door shut this season, and as both will be chasing maximum points against a potential relegation rival, there could be several goals at Stadio Sinigaglia.
Indeed, the two teams have an array of exciting forwards, who will take centre stage in an entertaining score-draw.
Genoa vs. Bologna (Saturday, 2.00pm)
Both failing to match expectations this season, Rossoblu rivals Genoa and Bologna will meet at Stadio Luigi Ferraris on Saturday afternoon.
After over-performing last term, the clubs now languish in the bottom half of the Serie A standings, with just two league wins between them.
We say: Genoa 0-1 Bologna
Genoa (60%) and Bologna (43%) top the list for highest percentage of goals scored during the final 15 minutes this season, so a late winner could decide what is sure to be a close-fought contest.
Momentum is going against the hosts and their head coach Alberto Gilardino, who will be left fearing for his seat in the Stadio Ferraris dugout after another defeat.
AC Milan vs. Udinese (Saturday, 5.00pm)
Unexpectedly trailing their less-heralded visitors in the Serie A standings, AC Milan will aim to overtake Udinese by winning at San Siro on Saturday.
Having lost to Fiorentina just before the international break, Milan sit two points behind the Friulani, who are flying high with four wins from seven so far.
We say: AC Milan 3-1 Udinese
Defensive doubts may always plague Paulo Fonseca's teams, but they often outscore more modest opposition - particularly on home turf.
While, on current form, Udinese can compete with most Serie A sides on their day, Milan will ultimately wrap up maximum points and move above their visitors in the table.
Juventus vs. Lazio (Saturday, 7.45pm)
Locked together on 13 points in the Serie A standings, Calcio heavyweights Juventus and Lazio will fight it out for three points on Saturday night, when the teams meet in Turin.
Though Juve had to settle for a disappointing draw before international football intervened, they sit within touching distance of top spot following an unbeaten start to life under Thiago Motta.
We say: Juventus 1-1 Lazio
With a number of players unavailable, Juventus may have to put up with another single-point haul, as Lazio seem to be heading in the right direction and have scored freely this season.
A share of the spoils would keep both teams in touch with the Serie A pace-setters, and neither would be too dissatisfied to walk away with a draw.