Gareth Southgate's Three Lions routed Albania 5-0 on Friday night to put them on the brink of winning Group I.
Now they just have to draw in San Marino, Fifa's worst ranked national team in world football, to secure their place at next winter's World Cup.
England beat San Marino 5-0 in their opening group game and Franco Varrella's side are pointless since, only scoring one goal.
It should be a routine night for Southgate and co but they must still get the job done.
San Marino v England: talkSPORT commentary
The Group I tie will kick-off at 7:45pm on Monday, November 15.
Adrian Durham will be your host and commentary will come from Jim Proudfoot and former England striker Dean Ashton.
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San Marino v England: Team news
Jack Grealish, Raheem Sterling, Luke Shaw, Jordan Henderson and Mason Mount have not travelled to San Marino.
Henderson and Grealish have returned to their clubs for assessment on injuries while Sterling is unavailable due to a personal matter.
Mount is recovering from dental surgery while Shaw remains out with concussion.
Goalkeepers: Sam Johnstone, Jordan Pickford, Aaron Ramsdale
Defenders: Trent Alexander-Arnold, Ben Chilwell, Conor Coady, Reece James, Harry Maguire, Tyrone Mings, John Stones, Kyle Walker
Midfielders: Jude Bellingham, Kalvin Phillips, Declan Rice, James Ward-Prowse, Emile Smith Rowe, Conor Gallagher
Forwards: Tammy Abraham, Phil Foden, Harry Kane, Marcus Rashford, Bukayo Saka
San Marino v England: What do the Three Lions need?
England have all-but sealed qualification on 23 points, with the Three Lions only needing a point against San Marino to seal their World Cup spot.
If the unthinkable happens and Southgate's side are defeated then Poland in second would need a victory over Hungary tonight and a six-goal swing.
Robert Lewandowski and co are currently on 20 points and a win against the Hungarians would still put them in contention of being seeded in the playoffs.
Albania are in third in Group I but are out of the running following their heavy loss at Wembley last week.
San Marino v England: What has been said?
England boss Gareth Southgate: "I think it is important, a game like tomorrow, we have set a benchmark in terms of the performance the other night and we know the expectation is to win comfortably.
"We know that we have got the quality to do that but you have to go and deliver it and to have leadership on the pitch and to have the right balance of characters and positional balance is just as important for a game against the team at the bottom of the group as it is against the teams at the top.
"We've wanted to make sure that people that are with us get the opportunities to play, the guys that have perhaps been starting in some of the bigger matches during the summer in particular, recognise that they also have a role to support everybody else when the time's right.
"When you have a squad, it is so important that those that aren't starting support the team that are. So I think that's a good process for everybody in the squad to experience.
"But equally, we want to make sure that the team we start with tomorrow, is a statement that we're here to do business, that we're taking this very seriously, we're not qualified yet.
"We want a strong performance, we've got thousands of England fans travelling and we must put on a performance that underlines all of the facts I've just spoken about."