On Tuesday evening, the Bayern Munich forward needed to be withdrawn during the first half of the Bundesliga fixture with what was later described as a tendon injury.
Although Julian Nagelsmann indicated after the game that it was 'not a big injury', reports emerged in France that Mane would miss out on representing his country in Qatar.
However, two days later, the 30-year-old has been named in Aliou Cisse's 26-man squad, heading a talent crop of players with a wide array of top-level experience.
As well as Mane, Chelsea duo Edouard Mendy and Kalidou Koulibaly are the headline selections, the trio having all starred when Senegal won the African Cup of Nations at the beginning of the year.
There are five other representatives from English football with Everton midfielder Idrissa Gueye and Watford winger Ismaila Sarr also in line for key roles.
Leicester City's Nampalys Mendy, Nottingham Forest's Cheikhou Kouyate and Tottenham Hotspur's Pape Sarr complete the list of players from English teams.
Abdou Diallo and Fode Ballo-Toure, of RB Leipzig and AC Milan respectively, will be expected to show their capabilities in the backline alongside Koulibaly.
Cisse has gone top-heavy with attacking options with Boulaye Dia, Bamba Dieng and Keita Balde - of Salernitana, Marseille and Spartak Moscow respectively - each bringing their own qualities in the final third.
The Lions of Teranga, who narrowly missed out on the knockout stages four years ago, have been placed in a group alongside Netherlands, Ecuador and Qatar.
Senegal begin their campaign with a fixture against the former in Doha on November 21.
Senegal's 2022 World Cup squad in full
Goalkeepers: Edouard Mendy (Chelsea), Alioune Badara Faty (Casa Sports), Bingourou Kamara (Montpellier)
Defenders: Saliou Ciss (free agent), Youssouf Sabaly (Real Betis), Kalidou Koulibaly (Chelsea), Pape Abou Cisse (Olympiacos), Abdou Diallo (RB Leipzig), Fode Ballo-Toure (AC Milan), Abdoulaye Seck (Maccabi Haifa), Bouna Sarr (Bayern Munich)
Midfielders: Idrissa Gueye (Everton), Nampalys Mendy (Leicester City), Cheikou Kouyate (Nottingham Forest), Pape Matar Sarr (Tottenham Hotspur), Moustapha Name (Pafos), Pape Gueye (Marseille)
Attackers: Boulaye Dia (Salernitana), Sadio Mane (Bayern Munich), Ismaila Sarr (Watford), Bamba Dieng (Marseille), Keita Balde (Spartak Moscow), Famara Diedhiou (Alanyaspor), Mame Thiam (Kayserispor), Habib Diallo (Strasbourg)