Episode 58 of the The Overlap's popular show saw Gary Neville, Paul Scholes, Jill Scott, Keane and Ian Wright return to the table.
Scott played in a Sellebrity Soccer charity game on Sunday and her side faced a Danny Dyer team featured an ex-Premier League star.
"I was the playing the charity game at the weekend, and Marlon Harewood absolutely smashed us," the former Lioness explained.
"Yeah, he was a big old thing, old Marlon," Wright replied before his co-pundit Keane crudely joked: "And what was the game like?"
The Manchester United legend said it with a cheeky grin and caused the other four members of the panel to burst into laughter.
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Neville and Scholes in particular had their hands in their arms on the table, seemingly in disbelief at their former teammate's comment.
"Roy you can't say that!" Wright responded whilst still laughing. "That's got to be [cut out of the edit]..."
Keane, who was still grinning, offered a defence for his remark when he said: "Oh no, what was the game like?"
Scott took it like a champ and told the producers to keep it in the show as Scholes claimed: "That's a step too far, that."
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"What was the score I mean, in the game," Keane asked as the panel's laughter began to die down, but it didn't stop there.
"It's such a powerful image!" Wright shouted, which caused Neville to spit out his water on the table and rekindle the chuckles.
Wright then claimed that he couldn't 'unsee it', before Scott joked to the camera: "I think this is our last show, thanks for tuning in."
As the hysteria finally calmed down, Keane once again asked what the score was in the charity match at West Ham's London Stadium.
Dyer's team won 5-4 against Scott's side, with Harewood scoring two goals on their way to victory.
The ex-striker made 136 Premier League appearances for Nottingham Forest, West Ham, Aston Villa and Blackpool, scoring 28 goals in total.