Carlo Ancelotti's side are top of the division, eight points ahead of second-placed Barcelona, while Athletic are fourth, one point clear of fifth-placed Atletico Madrid, and here Sports Mole rounds up the team news.
REAL MADRID vs. ATHLETIC BILBAO
REAL MADRID
Out: Vinicius Junior (suspended), Thibaut Courtois (knee), David Alaba (knee)
Doubtful: None
Sports Mole's predicted XI: Lunin; Carvajal, Rudiger, Nacho, Mendy; Valverde, Tchouameni, Kroos; Bellingham; Brahim, Rodrygo
ATHLETIC BILBAO
Out: Yuri Berchiche (hamstring)
Doubtful: Inigo Ruiz de Galarreta (muscle), Aitor Paredes (muscle), Ander Herrera (hamstring)
Sports Mole's predicted XI: Simon; De Marcos, Vivian, Yeray, Lekue; Benat, D Garcia; I Williams, Sancet, N Williams; Guruzeta
For data analysis of the most likely results, scorelines and more for this match please click here.