Carlo Ancelotti's side opened their Group D campaign with a 1-0 victory over Inter Milan on September 15, with Rodrygo scoring a late winner for Los Blancos at San Siro.
The capital giants will enter this contest off the back of a goalless draw with Villarreal, but they are top of La Liga, having collected 17 points from their first seven league games of the 2021-22 campaign.
Here, Sports Mole rounds up all of Real Madrid's injury and suspension news ahead of their battle with Sheriff, who beat Shakhtar Donetsk 2-0 in their Group D opener.
Gareth Bale
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Gareth Bale is set for an extended spell on the sidelines due to the hamstring injury that he picked up ahead of the clash with Celta Vigo on September 12.
Toni Kroos
Status: Major doubt
Type of injury: Hip
Possible return date: September 28 (vs. Sheriff)
Toni Kroos is working his way back from a hip problem and could potentially be in the squad against Sheriff, having trained alongside his teammates ahead of the clash with Villarreal.
Ferland Mendy
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Ferland Mendy is currently unavailable for selection due to a muscular problem, but the Frenchman has started to train on the grass at the club's training ground and could return soon after the international break.
Marcelo
Status: Major doubt
Type of injury: Muscle
Possible return date: September 28 (vs. Sheriff)
Marcelo has been struggling with a muscular problem in the early stages of the season and was again absent against Villarreal on Saturday, making him a major doubt for Tuesday's contest.
Dani Ceballos
Status: Out
Type of injury: Ankle
Possible return date: Unknown
Dani Ceballos sustained an ankle injury while on duty with Spain during the Tokyo 2020 Olympics and is not yet close to making his return for Ancelotti's side.
Dani Carvajal
Status: Out
Type of injury: Calf
Possible return date: Unknown
Dani Carvajal will be on the sidelines for the next month or so due to the calf problem that he picked up in the clash with Valencia on September 19.
REAL MADRID'S SUSPENSION LIST
Real Madrid have no players suspended for this match.
Fiorentina 
Udinese 
Benfica 
Estoril 
Inter 
Como 
Manchester City 
Everton 
Chelsea 
Fulham 
Nottingham Forest 
Tottenham 
Celtic 
Motherwell 
Wolverhampton 
Manchester Utd 
ST Mirren 
Rangers 
Sampdoria 
Carrarese 
Liverpool 
Leicester 
Arsenal 
Ipswich 
Cagliari 
Lazio 
Atalanta 
FC Porto 
Boavista 
Torino 
Napoli 
Venezia 
ST Johnstone 
Juventus 
West Ham 
Pisa 
AC Milan 
Roma 
Sporting CP 
Newcastle 
Brentford