An injury-ravaged Los Blancos drew 0-0 with Getafe on Sunday to lose ground in the La Liga title race.
Zidane's men are three points behind leaders Atletico Madrid ahead of this midweek trip to Cadiz, who can possibly climb into the top half of the division with a win.
Here, Sports Mole rounds up Madrid's latest injury and suspension news ahead of the clash at Estadio Ramon de Carranza.
Sergio Ramos
Status: Out
Type of injury: Calf
Possible return date: Unknown
Sergio Ramos has been sidelined with a mixture of a calf issue and a positive coronavirus test. Zidane has not indicated just how long his captain will remain absent.
Lucas Vazquez
Status: Out
Type of injury: Knee
Possible return date: Unknown
Versatile left-sided player Lucas Vazquez sustained a serious knee injury in the recent win against Barcelona and will not play again this season, meaning that he has possibly played his last game for the club.
Federico Valverde
Status: Major doubt
Type of injury: Isolation
Possible return date: April 21 (vs. Cadiz)
Federico Valverde was forced to sit out the Getafe draw after coming into close contact with someone who tested positive for coronavirus. Madrid are hopeful that the midfielder will be given the green light to return to training ahead of this trip to Cadiz.
Ferland Mendy
Status: Major doubt
Type of injury: Muscle
Possible return date: April 21 (vs. Cadiz)
Full-back Ferland Mendy sustained a muscular injury in training last week and remains a major fitness doubt for this contest, leaving Madrid particularly depleted at the back.
Raphael Varane
Status: Major doubt
Type of injury: Coronavirus
Possible return date: April 21 (vs. Cadiz)
Raphael Varane is another whose availability remains in the balance after testing positive for coronavirus on April 6. The centre-back failed to return a positive test ahead of the Getafe match and therefore remains a major doubt for this latest outing.
Eden Hazard
Status: Major doubt
Type of injury: Muscle
Possible return date: April 21 (vs. Cadiz)
Eden Hazard has been plagued by numerous injuries during his time at Madrid and is now nursing a muscular problem. The Belgium international returned to training last week, but he is almost certain to sit this one out.
Dani Carvajal
Status: Major doubt
Type of injury: Hamstring
Possible return date: April 21 (vs. Cadiz)
Dani Carvajal has been given an outside chance of featuring against Cadiz. The full-back is struggling with a troublesome hamstring issue, which has kept him out of action for the past two months.
REAL MADRID'S SUSPENSION LIST
Casemiro and Nacho served a suspension against Getafe but will be back involved on Wednesday.