As for Yeni Malatyaspor, their campaign will finish in relegation, with the hosts set to end the season bottom of the Super Lig.
Match preview
Unable to challenge champions Trabzonspor at the top of the Super Lig, Fenerbahce have been able to avoid the poor form that has hit the other big two sides in Turkey, with both Besiktas and Galatasaray set to miss out on European football.
On course for their highest league finish since 2017-18, Fenerbahce's return to Europe's premier competition will be a welcome one, with a qualification campaign awaiting the Yellow Canaries in the summer months.
With just the one game remaining, Fenerbahce will be wary of getting across the line with the sole point they need to secure second, with third-placed Konyaspor still within reach.
While Fenerbahce's superior goal difference should be enough to seal Champions League qualification, the side from Istanbul will be keen to secure the three points against an out of sorts Malatyaspor.
Confident heading into the clash, Fenerbahce having ended the domestic campaign strongly, with the Yellow Canaries unbeaten in their last 13 league matches.
Form only hosts Malatyaspor could dream of, Yeni enter the weekend on the back of nine straight league defeats in the Super Lig.
Unsurprisingly given their recent results, it was not enough for Malatyaspor to avoid the drop, and they will go down to the second tier rooted to the foot of the division.
Last victorious against Adana Demirspor back in early March, Malatyaspor's chances of a victory remain slim, given they have lost all but one of their last six meetings.
Malatyaspor's only win against Fenerbahce since August 2018 came away from home, with the omens not looking strong for Yeni this weekend.
Yeni Malatyaspor Turkish Super Lig form:
Fenerbahce Turkish Super Lig form:
Team News
Having ended his season early, Jospin Nshimirimana will not be in action for the hosts, as the midfielder is sitting the clash out through suspension.
Midfield partner Stephen Mallan is also missing this weekend, but unlike Nshimirimana, his absence is down to a hernia problem.
Limping towards the finishing like, the visitors have a number of injuries to contend with, as both Arda Guler and Min-Jae Kim will be out with muscle problems.
Similarly for Fenerbahce, a foot problem is keeping Miguel Crespo out of the side, which is the same injury preventing Dimitrios Pelkas from taking part this weekend.
Yeni Malatyaspor possible starting lineup:
Turkaslan; Awuku, Basdas, Campi, Hafez; Mujde, Tanis; Altintas, Cagiran, Altunisik; Tetteh
Fenerbahce possible starting lineup:
Bayindir, Sangare, Tisserand, Aziz, Kadioglu; Zajc, Gustavo; Osayi-Samuel, Kahveci, Rossi; Dursun
We say: Yeni Malatyaspor 0-3 Fenerbahce
The form book is clearly weighted in Fenerbahce's favour, with one team dominating matches at the upper end of the table, while the other has remained winless for months.