Although the two sides are currently sat in the top two of their Women's Champions League group, Wolfsburg are in pole position due to their superior goal difference.
Match preview
Wolfsburg made light work of their opening two Champions League games, after they followed a 4-0 win over St Polten with a 2-0 away victory against Slavia Prague.
Those results helped Wolfsburg begin the 2022-23 season with a run of 11 consecutive victories in all competitions before they were had to settle for a 1-1 draw by Roma.
Ewa Pajor equalised in the 33rd minute after Valentina Giacinti had given Roma an early lead, but neither side could find a winner in the second half.
Since drawing against Roma, Tommy Stroot's side have beaten Koln 4-0 and cruised to a comfortable 5-0 win over Eintracht Frankfurt at the weekend.
Wolfsburg are now unbeaten in 14 competitive games this season, and they will be looking to record a third consecutive victory on Thursday.
Meanwhile, Roma are still yet to lose in their first-ever Women's Champion League campaign, and their impressive form has left them on the brink of qualifying for the knockout stages.
Roma's European journey started in the qualifying rounds, where they had to beat three teams, including a penalty shootout victory over Paris FC.
After beginning the group stage with a narrow 1-0 win over Slavia Prague, Roma looked to be heading towards their first Champions League defeat when they trailed 2-0 in their away meeting with St Polten, but they showed great determination to battle back and claim a dramatic victory.
While Alessandro Spugna's side showed they belonged on the European stage by drawing with the German champions on matchday three, they are also six points clear of Juventus at the top of Serie A.
As they dream of claiming their maiden Serie A title, Roma will want to continue to build momentum as they look to extend their unbeaten run to 16 games in all competitions.
Wolfsburg Women Women's Champions League form:
W
W
D
Wolfsburg Women form (all competitions):
W
L
W
W
W
D
Roma Women Women's Champions League form:
Roma Women (all competitions) form:
Team News
After thrashing Frankfurt 5-0 at the weekend, Stroot could be tempted to name an unchanged lineup for Thursday's contest.
Kathrin Hendrich will continue her central defensive partnership with Dominique Janssen, and the pair will be aiming to help their side keep a third straight home clean sheet in all competitions.
Jill Roord scored a hattrick on Saturday, and she will operate behind Pajor, who has racked up goals in all competitions this term.
Like their hosts, Roma could also select an unchanged starting XI, which would see Camelia Caesar keep her place between the posts.
The goalkeeper will be shielded by the centre-back pairing of Carina Wenninger and Elena Linari, while Elisa Bartoli and Moeka Minami will operate as the two full-backs.
Giacinti will be looking to add to the 10 goals she has scored this season when she leads the line against Wolfsburg.
Wolfsburg Women possible starting lineup:
Frohms; Wilms, Hendrich, Janssen, Rauch; Lattwein, Oberdorf; Popp, Roord, Huth; Pajor
Roma Women possible starting lineup:
Ceasar; Bartoli, Wenninger, Linari, Minami; Serturini, Giugliano, Greggi; Andressa, Haavi, Giacinti