While the Hammers are playing their first continental fixture since winning the Europa Conference League, the visitors are participating in their first-ever group-stage European game.
Match preview
When the final whistle went in Prague back in June, West Ham's victory over Fiorentina in the Europa Conference League final brought about many things to look forward to.
Proving to be a more attractive option to new players was one of them, and David Moyes has sufficiently strengthened his squad to an extent where the Premier League outfit are capable of winning this competition.
That has been proven during their opening five domestic fixtures, West Ham collecting 10 points from a possible 15 and only losing to Manchester City having held a half-time lead.
The disappointment of that game will have lingered for Moyes and his squad, yet the Scot will be relishing a return to the continent for a third season in succession.
West Ham went through their entire European campaign in 2022-23 without suffering a single defeat along the way, even when Moyes made the decision to rotate his squad.
With James Ward-Prowse having hit the ground running in midfield and Mohammed Kudus eager to make an instant impression in attack, Backa Topola are under no illusions that they have been thrown in the deep end.
Losing in the Champions League third qualifying round to Braga by a 7-1 aggregate scoreline was deflating, despite it arguably being anticipated, yet the Serbian club were aware that they would be dropping back into the second-tier competition.
Despite their brief stay in the most prestigious tournament, FK TSC are one of the minnows of the Europa League having never made it through to the main stages in Europe.
Nevertheless, last season's top-flight runners-up sit above Partizan Belgrade and Red Star Belgrade on the domestic scene right now with 19 points from seven games, highlighting that they have the confidence to pose a threat in England's capital.
West Ham United form (all competitions):
Backa Topola form (all competitions):
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Team News
With a trip to Liverpool to come at the weekend, Moyes is expected to make numerous changes to his West Ham XI.
Goalkeeper Lukasz Fabianski should earn a chance between the sticks, while Konstantinos Mavropanos and Kudus can expect to receive their first starts for the club.
Thilo Kehrer, Aaron Cresswell, Said Benrahma and Danny Ings are also an option for Moyes, with Lucas Paqueta and Michail Antonio among those who could be handed a rest.
The Backa Topola starting lineup should be similar to the one which begun the 6-3 victory over Zeleznicar on Saturday, the visitors scoring two of those goals once changes had been made.
Milos Vulic and Milos Pantovic both came on as replacements to score in the second half, but it is unlikely that the contributions will lead to a recall.
That said, Vulic may be considered as an option to form a more defensive-minded three-man midfield ahead of Petar Stanic if Lazetic chooses to play with more caution.
West Ham United possible starting lineup:
Fabianski; Kehrer, Zouma, Mavropanos, Cresswell; Soucek, Alvarez; Bowen, Kudus, Benrahma; Ings
Backa Topola possible starting lineup:
Ilic; Antonic, Cvetinovic, Stojic; Vlalukin, Radin, Djakovic, Petrovic; Stanic; Jovanovic, Rakonjac
We say: West Ham United 4-0 Backa Topola
While West Ham will not be underestimating their opponents, this is as ideal start as they could have hoped for. Even if Moyes opts to make a number of alterations, the Hammers should have more than enough quality to breeze to victory on Thursday night.