David Moyes's side enter the contest on the back of a 1-1 draw with Gent in the first leg of their Europa Conference League quarter-final, while the Gunners let a two-goal lead slip at Anfield last weekend.
Match preview
Somehow still alive in their third-tier European quarter-final, West Ham goalkeeper Alphonse Areola came under siege from a barrage of Gent attacks at the Ghelamco Arena, and Moyes was left thanking his lucky stars that the Hammers were able to cling on for a slice of the spoils.
Following Nayef Aguerd's disallowed scrappy goal, Danny Ings got off the mark in continental competition to put West Ham into the ascendancy, but Hugo Cuypers swiftly levelled for a Gent side who can count themselves unfortunate not to be taking a slender advantage to the English capital.
Conference League commitments take a back seat for a few days, though, as Moyes's men endeavour to continue their capital supremacy following a smash-and-grab 1-0 win over Fulham last weekend, keeping them above the dotted line in 14th place for the time being.
With just three points separating West Ham from Nottingham Forest in 18th place, results on Saturday could drag the Hammers back into danger, but losing just one of their last four in the division has somewhat eased their demotion fears and the pressure on Moyes's tired shoulders.
Then again, that loss was the humiliating 5-1 defeat to Newcastle United at the London Stadium earlier this month - bringing an end to a five-game unbeaten home streak in the Premier League in abysmal fashion - and an Arsenal side aiming to right their Merseyside wrongs will not be in any sort of charitable mood.
The stage was set for Arsenal to end the miserable Anfield Premier League hoodoo that has bedevilled them since 2012, and silencing the Kop through Gabriel Martinelli and Gabriel Jesus's efforts had Mikel Arteta's men on course to do just that last Sunday.
However, once the spark was ignited in Liverpool fans' bellies, the hosts were a different beast - cutting the deficit in half through Mohamed Salah before the Egyptian sent a penalty wide - and Arsenal's public enemy number one Roberto Firmino headed home a deserved equaliser for the Merseyside giants.
Had it not been for a pair of scarcely-believable interventions from Aaron Ramsdale, Arsenal could have been travelling back to base without a point, as Arteta oversaw a timid second-half display which has put a sizeable dent in their title chances.
Now sitting six points clear at the summit, Arsenal's lead will be cut down to a mere three if Manchester City - who have a game in hand - see off Leicester City on Saturday, and the Gunners can ill-afford anything less than maximums before their season-defining trip to the Etihad later this month.
West Ham drew first blood at the Emirates back on Boxing Day, but Arsenal brought the festive cheer to North London by coming from behind to win 3-1 - their sixth triumph from seven against the Hammers since a Declan Rice-inflicted loss at the London Stadium in January 2019.
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Arsenal Premier League form:
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Team News
One silver lining for Moyes during West Ham's plight is the availability of his players, with only Gianluca Scamacca (knee) set to miss the visit of Arsenal as the Hammers weigh up whether the misfiring striker requires surgery.
The Hammers boss should therefore be working with an identical crop of players from the draw with Gent, but changes will no doubt be in order amid the quick turnaround, starting with ex-Gunner Lukasz Fabianski coming back in for Areola in goal.
Tomas Soucek, Kurt Zouma, Michail Antonio and Lucas Paqueta - who missed last weekend's win at Craven Cottage due to a knock - are also among the fresh-legged replacements at Moyes's disposal, while Declan Rice will captain the hosts against his admirers.
Over at the Emirates, Arsenal continue to sweat on the fitness of William Saliba, who is yet to return to training from a back injury and will not be risked unnecessarily with the trip to the Etihad in mind.
As a result, Rob Holding - who scored his first and only Premier League goal to date at the London Stadium last season - should start once more, while Takehiro Tomiyasu and Mohamed Elneny remain on the road to recovery from knee surgeries.
On a brighter note, Eddie Nketiah has rejoined the group after shaking off an ankle problem and could be in contention to make his comeback on Sunday, but his smart turn and finish against West Ham on Boxing Day will not be enough for a start here.
West Ham United possible starting lineup:
Fabianski; Kehrer, Ogbonna, Zouma, Cresswell; Bowen, Rice, Soucek, Benrahma; Ings, Antonio
Arsenal possible starting lineup:
Ramsdale; White, Holding, Gabriel, Zinchenko; Xhaka, Partey; Saka, Odegaard, Martinelli; Jesus
We say: West Ham United 1-3 Arsenal
Riling up the Anfield faithful contributed significantly to Arsenal's downfall against Liverpool, but they should experience no such psychological disadvantage in front of a discontent London Stadium crowd.