The home side head into this one looking to make it three wins from four matches, while the visitors will be aiming to avoid a fifth consecutive defeat.
Match preview
Wealdstone were victorious away from home for the second game running courtesy of a 2-1 triumph over York City at the LNER Community Stadium.
Stuart Maynard's men wen behind to Immanuelson Duku's early opener before drawing level through Miguel Freckleton after which Jack Cook grabbed the winner in second-half stoppage time.
As a result, The Royals have moved up to 13th place in the National League table, four points behind the last playoff spot with a game in hand.
Next up is a first-ever meeting against an opposing outfit who finished bottom of the 2021-22 League Two campaign with just 26 points from 46 outings.
Currently on a seven-game winless streak in front of their fans, Saturday's hosts will need to turn things around on home turf to stand any chance to clinching a place in the postseason.
Scunthorpe United suffered a fourth straight defeat as they were narrowly beaten 2-1 by Dagenham & Redbridge in the sides' encounter at Victoria Road.
After going behind to Harry Phipps's strike 14 minutes in, Tony Daws's men hit back midway through the first half thanks to Andrew Boyce, only for Jay Bird to decide the game five minutes from time.
Having picked up just one point from the last 15 available, The Irons remain firmly in the relegation zone and sit three points adrift of safety as things stand.
With no wins in 11 matches on the road across all competitions this term, Saturday's visitors now prepare for what is set to be another difficult assignment on enemy territory.
Wealdstone National League form:
L
L
L
W
D
W
Scunthorpe United National League form:
W
D
L
L
L
L
Team News
After spending the opening weeks of the current campaign on the bench, Alex Dyer has returned to the starting lineup in recent weeks and will be expected to retain his place.
In what was only his second senior appearance since joining from Sheffield United, Miguel Freckleton opened his account for Wealdstone last time out.
Scunthorpe's Joseph Nuttall was absent from his side's defeat to Dag & Red through suspension but this weekend's away side will be able to call upon their leading scorer once again.
This should see Markus Carver drop out of the XI to the bench off the back of a rare start for the 29-year-old forward in the aforementioned game
Wealdstone possible starting lineup:
Howes; Freckleton, Kinsella, Barker, Cook; Allarakhia, McGregor, Charles, Dyer; Obiero, Olomola
Scunthorpe United possible starting lineup:
Dewhurst; Pugh, Boyce, O'Malley, Taft; Rowe, Butterfield, Beestin, Apter; Lavery, Nuttall