On the other hand, the away side make the journey to Arnhem this weekend in search of what would be a fourth league triumph in five matches.
Match preview
Twente ran out comfortable 3-0 winners against Go Ahead Eagles when the teams locked horns at De Grolsch Veste Stadion on Sunday afternoon.
Joseph Oosting's men raced to a two-goal lead thanks to Sem Steijn's first-half double after which Joshua Brent put the result beyond doubt 15 minutes into the second period.
Consequently, The Tukkers remain third in the Eredivisie table, eight points behind Feyenoord and a further 10 adrift of leaders PSV Eindhoven.
Awaiting the Enschede-based side next is the challenge of an opposing outfit who have picked up just one win from the last seven editions of this fixture.
Having recently ended a three-game winless run on the road, Saturday's visitors now go in search of consecutive wins away from home for the first time since October.
Vitesse showed great resolve to claim a 2-1 victory over SBV Excelsior in a crunch relegation clash at Van Donge & De Roo Stadion on Sunday.
After going behind to Lance Duijvestijn's opener, Edward Sturing's men levelled matters through Paxten Aaronson before Nicolas Isimat-Mirin completed the turnaround four minutes from time.
With 16 points picked up from 23 matches this term, Geel en Zwart sit bottom but one in the league standings, five points adrift of safety.
Currently with the fewest goals scored on home turf in the division, Saturday's hosts have work to do at the top end of the pitch as they go in search of a first home league win of 2024.
Vitesse Eredivisie form:
L
L
L
L
D
W
Vitesse form (all competitions):
L
L
L
L
D
W
FC Twente Eredivisie form:
L
D
W
W
L
W
Team News
Miliano Jonathans and Fode Fofana remain unavailable for Vitesse through knee injuries, although the latter is not far off making his comeback as things stand.
Midfielder Davy Propper has missed five cames in a row for the home side through a muscle injury and is not expected to feature this weekend.
Following his double against Go Ahead Eagles, Twente's Sem Steijn is now up to 12 league goals for the season - just three shy of his personal best of 15.
Steijn also scored the winning goal in the last meeting between Saturday's opponents and the 22-year-old will be looking to deliver the goods once again.
Vitesse possible starting lineup:
Room; Pinto, Isimat-Mirin, Oroz, Arcus; Meulensteen, Kozlowski, Aaronson; De Regt, Meerdink, Hadj Moussa
FC Twente possible starting lineup:
Unnerstall; Smal, Propper, Hilgers, Brenet; Sadilek, Eiting; Vlap, Steijn, Rots; Van Wolfswinkel