For the visitors, this weekend's clash is nothing more than a dead rubber having already suffered relegation from the top tier of Dutch football.
Match preview
Vitesse saw their three-game unbeaten streak come to an end against Fortuna Sittard following a 2-0 defeat when the sides faced off at the Fortuna Sittard Stadion on Sunday.
Phillip Cocu's men went behind to Paul Gladon's in the early exchanges of the second half before Umaro Embalo put the final in the coffin with 15 minutes left to play.
As a result, Geel en Zwart remain 13th in the Eredivisie table, clear of the relegation zone by just three points with as many matches left to play.
Coming up next is the challenge of an opposing outfit who are without defeat in the last eight editions of this fixture since 2014, winning six of them.
Having recorded back to back clean sheets on home turf for the first time in over a year, Sunday's hosts will be confident of keeping their visitors at bay.
Cambuur were beaten for the seventh league game running as they fell to a 3-0 defeat against FC Utrecht at the Cambuur Stadion on Saturday evening.
Sjors Ultee's men found themselves two down at half time thanks to strikes from Sander van de Streek and Anastasios Douvikas before Douvikas grabbed his second of the game from the penalty spot.
With 16 points from 31 matches so far, the Yellow-Blues remain rooted to the bottom of the standings, 12 points adrift of safety and headed for the Eerste Divisie.
Off the back of five straight away defeats by a combined score of 17-4 leading up to Sunday's clash, the away side now prepare for what is set to be another tough assignment on the road.
Vitesse Eredivisie form:
D
L
W
W
D
L
Cambuur Eredivisie form:
L
L
L
L
L
L
Team News
Maxim Gullit remains unavailable for Cambuur due to a long-term knee injury which has seen the 21-year-old fail to feature all-season long.
The away side will also be without the services of Robin Maulun and Vincent Pichel, while Joao Virginia is yet to recuperate from a thigh problem.
Davy Propper is a guaranteed absentee for Vitesse as the Dutchman continues to battle with a knee problem since the first week of February.
Sondre Tronstad has had to make do with a place on the bench for the each of the visitors' last three games but he could be recalled to the starting XI for this one.
Vitesse possible starting lineup:
Scherpen; Wittek, Isimat-Mirin, Flamingo, Arcus; Van Ginkel, Bero, Meulensteen; Kozlowski, Sankoh, Manhoef
Cambuur possible starting lineup:
Ruiter; Wermeskerken, Mac-Intosch, Smand, Bangura; Jacobs, Hoedemakers, Van Kaam; Foor, Uldrikis, Mahi