The Arnhem-based outfit ended the regular season in sixth place, 10 points and one place behind their opponents AZ in fifth.
Match preview
Vitesse headed into their playoff semi-final with Utrecht after winning only three of their final 13 games of the season, and after losing 3-1 in the first leg, their hopes of turning the tie around seemed slim.
However, goals from Million Manhoef and Sondre Tronstad secured a 2-0 second-leg win and forced the tie into extra time, before Nikolai Frederiksen scored three minutes after the interval to put Vitesse in front on aggregate.
Frederiksen was then dismissed in the closing stages of extra time after picking up a needless second yellow card, but Vitesse held on to win and progress to the playoff final.
Thomas Letsch's side are now just two games away from securing Europa Conference League football for the second successive season, after reaching the last-16 stage earlier this term.
Success on Thursday, however, could prove challenging as they have only won two of their last eight meetings against AZ Alkmaar.
Similarly to Vitesse, AZ Alkmaar endured a disappointing run of form at the end of the regular season, winning only one of their final seven Eredivisie matches.
Their four-game winless run was then extended to five when they lost 3-2 away at Heerenveen in the first leg of their playoff semi-final last Thursday. However, they returned to winning ways on Sunday with a 2-0 home victory in the reverse fixture.
Dani de Wit and Zakaria Aboukhlal were both on the scoresheet to help the Cheeseheads win 4-3 on aggregate and progress to the playoff final.
Pascal Jansen's men have scored in each of their last 14 away matches across all competitions, but they have failed to win any of their last six on the road during this run.
AZ have also failed to win any of their last four away meetings with Vitesse, but they did claim four points against them in the league this season - drawing 0-0 on the road before winning 3-1 on home soil - so they can take some confidence into Thursday's clash.
Vitesse Eredivisie form:
AZ Alkmaar Eredivisie form:
Team News
Vitesse will be without Maximilian Wittek (shoulder), Yann Gboho (groin) and Jacob Rasmussen (muscle) due to injury, while Frederiksen will miss the first leg through suspension.
Letsch is unlikely to make too many changes, if any, to his starting lineup, with a midfield diamond of Tronstad, Patrick Vroegh, Matus Bero and Toni Domgjoni all set to keep their places.
Top scorer Lois Openda, who has 18 Eredivisie strikes to his name, is expected to be joined in attack by either Thomas Buitink or Adrian Grbic.
As for AZ Alkmaar, left-back Owen Wijndal is a minor doubt and will be assessed ahead of kickoff, while Jeremy Helmer and Jelle Duin both remain sidelined with injuries.
Yukinari Sugawara could replace Aslak Fonn Witry at right-back, while Hakon Evjen, Dani de Wit and Jesper Karlsson are all set to keep their places in behind striker Vangelis Pavlidis.
Vitesse possible starting lineup:
Schubert; Dasa, Bazoer, Doekhi, Manhoef; Tronstad; Bero, Vroegh; Domgjoni; Grbic, Openda
AZ Alkmaar possible starting lineup:
Jensen; Sugawara, Hatzidiakos, Martins Indi, Wijndal; Clasie, Midtsjo; Evjen, De Wit, Karlsson; Pavlidis
We say: Vitesse 1-1 AZ Alkmaar
Both Vitesse and AZ will head into Thursday's fixture in high spirits after coming from behind to progress on aggregate in the semi-finals.